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Acute kidney failure was reported in one case involving an athlete taking over 10 grams daily of creatine for 6 weeks. Creatine should not be used by anyone who already has problems kidney function, high blood pressure, or liver disease.
Creatine may increase the likelihood of damage to the kidneys if taken with cimetidine (Tagamet, a medication used for heartburn and to prevent ulcers), diuretics, probenecid (used for gout), or non-steroidal anti-inflammatory (NSAID) medications (such as ibuprofen or Advil).
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